How old is your brain and why does this matter? The neuroimaging brain-age paradigm.

Lecturer: James Cole (UCL CMIC and Dementia Research Centre)

The brain changes as we age, and these changes are associated with cognitive decline and dementia risk. This motivates research using neuroimaging to measure the brain ageing process. I will present my work on the ‘brain-age’ paradigm, derived using machine learning analysis of MRI data. I will present results from brain-age studies of the general population and Down’s, HIV, traumatic brain injury, multiple sclerosis, and dementia, alongside my UK Biobank analysis on multiple MRI modality brain-age. Finally, I will talk about new developments, including voxelwise brain-age and